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Coeliac Disease and Gluten Sensitivity Blood Test

Coeliac Disease and Gluten Sensitivity Blood Test

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The Coeliac and Gluten Sensitivity Profile is a health tool aimed at identifying coeliac disease and gluten sensitivity. These conditions, which are prevalent yet often overlooked, can significantly impact quality of life.

Coeliac disease affects about 1% of the global population, but up to 80% of cases are estimated to go undiagnosed. Gluten sensitivity is even less understood, potentially impacting up to 1 in 17 people. Many of these undiagnosed individuals experience a range of disruptive symptoms such as digestive discomfort, fatigue, skin rash, or even neurological issues, without realising that these could be linked to their diet.

Testing for TTG antibodies is recommended by the NHS to rule out Coeliac disease as a cause of persistent fatigue or gastrointestinal problems.

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Markers Included In The Test

Endomysial Antibodies IgA: Endomysial antibodies (EMA) IgA are autoantibodies that target the connective tissue around muscle fibers, and their presence in blood is highly indicative of coeliac disease, a condition where the body's immune system reacts abnormally to gluten, causing damage to the lining of the small intestine.

Gliadin deamidated lgG: This test is primarily used in the diagnosis and monitoring of celiac disease and other gluten-related disorders. Elevated levels of gliadin deamidated IgG antibodies can indicate an immune response to gluten in individuals with celiac disease or gluten sensitivity.

Tissue Transglutaminase (IgA): Tissue Transglutaminase (IgA) is an autoantibody that targets tissue transglutaminase, an enzyme found in the gut. In this autoimmune disorder, the immune system targets the body's own digestive system, leading to inflammation and damage to the lining of the intestines. This can cause symptoms such as digestive discomfort, malabsorption of nutrients, weight loss, and fatigue.

Total IgA*: Total IgA measures the overall level of Immunoglobulin A (IgA) in your blood. IgA is an antibody that plays a crucial role in the immune function of mucous membranes, protecting against infections of the mucosal surfaces like those in the airways or digestive system. Both low and high levels can indicate an underlying immune disorder, leading to increased susceptibility to infections or autoimmune conditions.