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Epstein-Barr Virus Reactivation and Immune Response Blood Test

Epstein-Barr Virus Reactivation and Immune Response Blood Test

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The Epstein-Barr Virus (EBV) reactivation and immune response test measures antibodies (IgG and IgM) associated with EBV components and EBV DNA using PCR testing.

The presence of antibodies can reveal if someone has had a recent or past infection, as well as provide insight into your body’s immune response, while the presence of EBV DNA in the blood is an indication of active EBV replication and can be used to determine the viral load. Combining these two tests allows the assessment of EBV reactivation and to differentiate between active, recent and past infections.

Epstein-Barr Virus (EBV) is a ubiquitous virus known to establish lifelong, latent infection in the majority of the world's population. Active, replicating EBV has been documented in Long Covid and ME/CFS patients, and some studies have found that ME/CFS patients have higher rates of active EBV than the general population.

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Markers Included In The Test

EBV VCA IgM: Epstein-Barr Virus Viral Capsid Antigen (EBV VCA) IgM is an antibody produced by the immune system in response to an early phase of Epstein-Barr virus infection. High levels of EBV VCA IgM in the blood can indicate an active or recent EBV infection.

Epstein-Barr Virus PCR: The Epstein-Barr Virus DNA test detects the presence of EBV DNA in your blood, which indicates active EBV viral replication and infection

VCA IgG: VCA IgG is an antibody produced in response to infection with the Epstein-Barr virus (EBV). High levels can indicate past or recent infection with EBV, which is associated with various health conditions ranging from infectious mononucleosis (glandular fever) to chronic fatigue syndrome (including ME/CFS).

EBNA IgG antibody: EBNA IgG antibody is an autoantibody that targets the nucleus of cells. Elevated levels can indicate an autoimmune condition or, in some cases, an ongoing immune response to a chronic infection like Epstein-Barr virus (EBV).