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Metabolic Imbalance and Long-Term Monitoring

Metabolic Imbalance and Long-Term Monitoring

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The Metabolic Imbalance and Long-term Monitoring test is a tool for investigating metabolic dysfunctions often observed in chronic diseases like Long Covid and ME/CFS. Metabolic dysfunction can lead to various issues including fatigue, acidosis, impaired energy production in cells, sleep problems, hormonal imbalances, weight problems, and difficulty concentrating.

This panel tests markers that give an insight into metabolic health, as well as inflammation and insulin sensitivity. It also includes the Lactate Pyruvate Ratio, a key marker for mitochondrial function, and citrate which can indicate disruptions in energy production.

Uncovering metabolic imbalances or monitoring changes over time can guide practitioners to personalise treatments and lifestyle modifications or preventative measures, offering a path towards improved health and quality of life.

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Markers Included In The Test

Adiponectin: Adiponectin is a hormone produced by fat cells that helps regulate glucose levels and the breakdown of fatty acids. Low levels of adiponectin are associated with obesity, insulin resistance, and an increased risk of type 2 diabetes and heart disease.

C-reactive Protein (High Sensitivity) (hsCRP): High Sensitivity C-reactive Protein (hsCRP) is a protein produced by the liver in response to inflammation or infection. Elevated hsCRP levels can indicate ongoing inflammation or infection, and are associated with an increased risk of heart disease, stroke, and chronic conditions such as diabetes.

Citrate (Blood): Citrate is a crucial component in the body's process of energy production. When citrate levels in the blood are too high or too low, it can signal issues with how your body is producing energy, which can be linked to disruption in energy metabolism or the presence of certain health conditions such as kidney disease or metabolic acidosis. Low levels can suggest problems with the citric acid cycle and energy production. Impaired citrate response after exertion has been documented in patients with ME/CFS.

Glucose: Glucose is the primary source of energy for your body's cells. Glucose levels in the blood are tightly regulated to maintain stable and appropriate levels. High blood glucose levels can indicate diabetes or pre-diabetes, while low levels can point to hypoglycemia, both of which can have significant health implications if not controlled.

HbA1c: Hemoglobin A1c (HbA1c) is a form of hemoglobin that is chemically linked to sugar (blood glucose). The HbA1c test provides an average of your blood sugar levels over the past two to three months. High levels can be a sign of long-term elevated blood sugar, indicating potential diabetes or poor diabetes management.

Insulin: Insulin is a hormone produced by the pancreas to regulate blood glucose levels. High levels may indicate insulin resistance or type 2 diabetes, while low levels can suggest type 1 diabetes, where the body isn't producing enough insulin.

Lactate Pyruvate Ratio: The Lactate Pyruvate Ratio is a measure used to assess cellular and mitochondrial energy metabolism. An elevated ratio can suggest a shift towards anaerobic metabolism, often associated with mitochondrial dysfunction, potentially causing fatigue and other symptoms. A high ratio may also be indicative of lactic acidosis, a condition that can lead to muscle weakness and other systemic problems

Lipid Profile: The Lipid Profile is a group of tests that measure different types of fats (lipids) in the blood, such as LDL ("bad") cholesterol, HDL ("good") cholesterol, and triglycerides. These measures can help assess the risk of developing cardiovascular disease. High levels of LDL or low levels of HDL can indicate a higher risk, while a healthy lipid profile supports cardiovascular wellbeing.